U.S. scientists make breakthrough in tuberculosis research

Researchers at the Massachusetts Institute of Technology (MIT) have developed a new method to label and track key components of Mycobacterium tuberculosis, marking a significant advance in the fight against tuberculosis.

According to a study published in the journal Proceedings of the National Academy of Sciences (PNAS), the team created a technique to selectively visualize the glycan ManLAM, a crucial element of the pathogen’s cell wall. Using an organic molecule called oxaziridine, scientists were able to trace the behavior of the glycan during infection of immune cells.

Contrary to previous assumptions, the study showed that the glycan remains in the bacterial cell wall for several days after infection, offering new insights into TB pathogenesis.

Current TB diagnostics, such as X-rays and molecular tests, are often inaccessible in developing countries. The new method could pave the way for rapid, urine-based diagnostic tests and more sensitive detection tools, potentially replacing time-consuming bacterial cultures.

N.Tebrizli